Employment：

Deputy Director of Gynecologic Oncology Department, The Women’s Hospital Affiliated to School of Medicine, Zhejiang University

Deputy Director of the Gynecologic Oncology Ward, The Women’s Hospital Affiliated to School of Medicine, Zhejiang University

Deputy Director of the Graduate Education Office, Zhejiang University School of Medicine

Reviewer for journals Cell cycle, BMC Cancer, Bioengineered, and Guangdong Medicine

Vice President of Maternal and Child Health Hospital of Changshan, Zhejiang Province

Visiting Scholar, National Institutes of Health (NIH) Cancer Institute (NCI)

Research areas:

The mechanism of drug resistance in gynecological tumors, especially ovarian cancer.

The tumor microenvironment and molecular mechanism of ovarian cancer metastasis.

Achievements:

Publish more than 40 papers in authoritative journals, with at least 1,000 citations and 190 single citations, of which 15 papers were published in international journals as the first author/co-first author/corresponding author/co-corresponding author.

Preside over 7 scientific research projects (2 national natural science fund projects), 4 talent projects, 1 educational project, and participate in 5 national natural projects and 1 provincial natural project.

Preside over 1 utility model patent, and 2 national invention patents, and participate in 1 national invention patent (the United States, which has been transformed).

Publications：

1. Yangyang Li#, Yixuan Cen#, Yifeng Fang #, Sangsang Tang, Sen Li, Yan Ren, Hongbo Zhang*, Weiguo Lu*, Junfen Xu*. Breaking the Iron Homeostasis: A “Trojan Horse” Self-Assembled Nanodrug Sensitizes Homologous Recombination Proficient Ovarian Cancer Cells to PARP Inhibition. ACS-Nano, 2022.8.3 online. https://doi.org/10.1021/acsnano.2c04956.

2. Junfen Xu#,*, Yifeng Fang#, Kelie Chen, Sen Li, Sangsang Tang, Yan Ren, Yixuan Cen, Weidong Fei, Bo Zhang, Yuanming Shen*, Weiguo Lu*. Single-Cell RNA Sequencing Reveals the Tissue Architecture in Human High-Grade Serous Ovarian Cancer. Clin Cancer Res. 2022; 28(16):3590-3602.

3. Yixuan Cen#, Yifeng Fang#, Yan Ren, Shiyuan Hong*, Weiguo Lu*, Junfen Xu*. Global characterization of extrachromosomal circular DNAs in advanced high grade serous ovarian cancer. Cell Death Dis. 2022;13(4):342.

4. Haibin Liu#, Junfen Xu#, Yanqin Yang, Xiaohong Wang, Ethan Wu, Vladimir Majerciak, Tingting Zhang, Renske D M Steenbergen, Hsu-Kun Wang, Nilam S Banerjee, Yang Li, Weiguo Lu, Craig Meyers, Jun Zhu, Xing Xie, Louise T Chow*, Zhi-Ming Zheng*. Oncogenic HPV promotes the expression of the long noncoding RNA lnc-FANCI-2 through E7 and YY1. Proc Natl Acad Sci USA. 2021. 118(3):e2014195118.

5. Junfen Xu#, Yang Li#, Fenfen Wang, Bei Cheng, Feng Ye, Xing Xie, Caiyun Zhou, Weiguo Lu*. Suppressed miR-424 expression via upregulation of target gene Chk1 contributes to the progression of cervical cancer. Oncogene. 2013; 32(8): 976-87.