Research Team
The team of research on precision screening and immunotherapy of uterine malignancies
Team leader：Hui Wang Professor&Chief Physician;Junbin Qian Hundred Talent Research Professor
Although the three-step diagnosis routine is an internationally established method for diagnosing cervical cancer, it remains expensive and inaccurate. The team intends to establish a new strategy for accurate screening and triage of cervical cancer on account of HPV integration detection, by drawing a hotspot map of HPV integration into the human genome and revealing the mechanism of HPV integration. The team also plans to discover the roles and mechanisms of multiple miRNAs in the carcinogenesis of HPV-positive cervical cancer. The team will use single-cell multi-omics technology to draft a high-resolution single-cell map of the disease microenvironment, and establish a new molecular typing method for endometrial cancer, cervical cancer and other uterine malignancies. On this basis, a stratified treatment strategy for these malignancies can be further performed. Using single-cell sequencing technology and immune repertoire to discover tumor-specific antigens and corresponding T cell receptor sequences, the team will construct ready-to-use and personalized antigen peptide libraries for cancer patients, and develop new cellular immunotherapy technology targeting tumor-specific antigens
Team leader
Chief members
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Xiao Li -
Qiu Tang -
Jiale Qin -
Junfen Xu -
Yidan Liu -
Peige Song -
Lili Chen -
Bingjian Lv -
Yuanming Shen -
Yang Li -
Songfa Zhang -
Fenfen Wang -
Chen Li -
Ni Sima
The team of research on metastasis and drug resistance mechanism and new treatment technologies of ovarian cancer
Team leader：Xiaodong Cheng Chief Physician;Yan Lu Professor
Ovarian cancer metastasis, drug resistance and recurrence are still the main causes of death of patients. The team intends to study the genetic and epigenetic regulation mechanism of ovarian cancer metastasis, and then reveal the molecular process of ovarian cancer metastasis. The team will use multi-omics technology to screen molecular targets related to drug resistance and elucidate the mechanism of action of key molecules; establish a high-throughput drug or small molecule compound screening platform based on organoid models to find new molecular drugs that can reverse drug resistance, as well as its chemical modification and improvement, and rapidly advance clinical translation. The team members are committed to developing new antibody-based immunotherapy methods to activate T cells for anti-tumor effect. They will build a comprehensive research platform for the biological effects of ultrasound to conduct ultrasound-mediated precise targeted therapy for gynecological tumors and the mechanistic research on reversing tumor resistance.
Team leader
Chief members
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Pengfei Xu -
Jiang Zhu -
Xiaofei Zhang -
Yun Liao -
Qiongzi Qiu -
Huimei Zheng -
Chih-Hung Hsu -
Qiang Liu -
Sen Li -
Kui Li -
Guiping Du -
Qiaohua Peng
The team of research on pathogenesis and personalized comprehensive diagnosis and treatment of endometriosis
Team leader：Xinmei Zhang Chief physician, Professor;Wanzhong Ge Research Professor
Endometriosis is a common and frequently-occurring disease in gynecology. Pain is its main clinical symptom, which seriously affects women's quality of life. The team will use transcriptomics to screen genes and non-coding RNAs related to pain severity to reveal a new mechanism of neuroinflammatory pain in endometriosis. Through the spatial transcriptomics, the team members are devoted to studying the key pathways and regulatory mechanisms of pain in endometriosis comprehensively associated with the related nerve fibers, vascular distribution and dorsal root ganglion neuron. Based on the above studies, the mechanisms of visceral referred pain and central pain hypersensitivity associated with endometriosis will be further elucidated. In addition, they will elucidate the regulatory mechanism of the immune microenvironment in endometriosis by single-cell sequencing technology, and carry out precise treatment under visualized ultrasound navigation using new nano-packaged drugs and sustained-release systems.
Team leader
Chief members
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Xiufeng Huang -
Yangyang Li -
Jianzhang Wang -
Shaojie Ding -
Gen Zou -
Yongchao Lu -
Jianhu He -
Hong Zhan -
Xiaofen Jin -
Yumiao Niu -
Feiting Xie -
Bingqing Liu
Addr: 268 Kaixuan Rd, Hangzhou 310029, P.R. China
Tel: 0571-86971817
Email: 
