Biography:

Dr Wang has been engaged in the clinical work of obstetrics and gynecology in Women’s hospital,  Zhejiang University School of Medicine,since 2003, and has been engaged in clinical, teaching and scientific research work for a long time. She is practised at diagnosis and treatment of all kinds of common diseases of obstetrics and gynecology, especially common gynecologic benign and malignant tumors including cervical intraepithelial neoplasia, cervical cancer, endometrial cancer, ovarian cancer, hydatidiform mole and gestational trophoblastic tumor. She is skilled in the comprehensive treatment of gynecological malignant tumors, such as surgery, minimally invasive surgery, fertility preservation and chemotherapy, and the treatment of various difficult and critical conditions. At the same time, she focus on research on the clinical, pathogenesis and chemoresistance mechanism of gynecological malignant tumors. She took charge of two two successfully completed research supported by the National Natural Science Foundation of China and one ongoing research supported by the Natural Science Foundation of Zhejiang Province, and participated in more than ten research grants of nation and province. She has published more than ten papers as the first or co-author or corresponding author. As a member of Gynecology and Obstetrics professional quality Control Center of standardized resident training in Zhejiang Province, she participated in the Zhejiang Province resident training senior teacher training, and was awarded as the excellent instructor of senior resident teacher training in Zhejiang Province several times. In 2018, she was awarded the 8th “Liu Tianxiang” Award in Women’s hospital, Zhejiang University School of Medicine, . In 2019, she was awarded as the national outstanding teacher of the clinical residency standardized training. In 2021, she was chosen as the training object of emerging medical talents in Zhejiang Province.

Academic Degrees:

Ph.D. Department of Obstetrics and Gynecology, Zhejiang University，School of Medicine, P.R.China. (2012).

M.S. Department of Obstetrics and Gynecology, Zhejiang University，School of Medicine, P.R.China (2003).

Professional Career:

2003-2005 Resident Doctor, Women's Hospital, Zhejiang University School of Medicine.

2006-2016 Attending Physician,Women's Hospital, Zhejiang University School of Medicine.

2017-- Associate chief physician, the Department of Gynecological Oncology, Women's Hospital, Zhejiang University School of Medicine.       

Research Areas of Expertise and Interests:

1. Pathogenesis of gynecological malignant tumor

2. High risk HPV infection in cervical cancer.

3. Diagnosis and treatment of ovarian cancer.

Honors:

1. 2011 "Travel Award" in the oral presentation of the 27th International Papilloma Conference (Berlin, Germany).

2. 2013/2014/2017/2019 “Advanced Worker" in Women’s Hospital, School of Medicine, Zhejiang University.

3. Project named “The new screening technique investigation and construction of prevention system for cervical cancer”in 2015 wined the First Prize of Zhejiang Medical and Health Science and Technology Award (8/17) (Lv Weiguo, Cheng Xiaodong, Hua Shaobing, Xie Xing, Wang Xinyu, Ye Feng, Li Yang, Wang Fenfen, Shen Yuanming, Hu Jiefeng, Li Baohua, Ye Jing, Li Ying, Ding Tian, Tian Qifang, Zhou Qingli, Ye Yiqing)

4. 2017/2019 "Top Ten Excellent Teaching Teachers" in Women’s Hospital, Zhejiang University School of Medicine.

5. 2017/2019/2020/2021 Excellent Instructor for Senior teacher training of standardized resident Training in Zhejiang Province (Zhejiang University,School of Medicine)

6. 2018 the 8th “Liu Tianxiang” Award in Women’s hospital, Zhejiang University, School of Medicine.

7. Project named “The new screening technique investigation and construction of prevention system for cervical cancer” wined the First Prize of National Higher Education Science and Technology (7/12)(Lv Weiguo, Cheng Xiaodong, Xie Xing, Wang Xinyu, Ye Feng, Li Yang, Wang Fenfen, Shen Yuanming, Hu Jiefeng, Ding Tian, Tian Qifang, Ye Yiqing)

8. 2019 the national outstanding teacher of the clinical residency standardized training

9. 2021 the training object of emerging medical talents in Zhejiang Province.

Professional Activities:

1. Member of Youth Committee of Gynecological Cancer Branch of Chinese Anti-cancer Association

2. Deputy director of Youth Committee of Gynecological Cancer Branch of Zhejiang Medical Association

3. Member of Youth Committee of Gynecological Cancer Branch of Zhejiang Anti-cancer Association

4. Member of Precise Diagnosis and Treatment of Cancer Professional Committee of Zhejiang Anti-cancer Association

5. Member of Gynecology and obstetrics professional quality control Center for standardized resident training in Zhejiang Province

6. Member of Gynecology and Obstetrics Branch of Zhejiang Translational Medical Association

7. Member of the first session of Cancer and Reproduction Branch of Chinese Eugenic Science Association

Grant Support:

1) Natural Science Foundation of Zhejiang Province/Exploration Project not Q, LY21H160032，The roles and mechanisms of SPDEF induced EMT via modulating TGFβ1 signal transduction pathway in development of Cervical cancer,2021/01-2024/12，100 thousand yuan，under research, Project Leader.

2) Education Department of Zhejiang Province，NBM+EBM mode applied in training of gynecological oncology interns Y202045696，2020.10.30-2022.10.31，Project Leader.

3) National Natural Science Foundation General project，81672568，The roles and mechanisms of SIRT5 induced deacetylation of p53 via p300/CBP in cervical cancer，2017/01－2020/12，570 thousand yuan, completed, Project Leader.

4) National Natural Science Foundation for Youth Fund，81302248，The mechanisms and roles of differentiation induced by miR-375/JunD pathway in persistent infection of HPV，2014/01－2016/12， 230 thousand yuan, completed, Project Leader.

5) National Natural Science Foundation of China Youth Fund，81802587，The basic research in new “virus-like”construct carrier for gene medicine in reproductive tract, 2019/01-2021/12，210 thousand yuan，under research, participant (second)

6) Provincial Natural Science Foundation/Exploration Project Y，LY19H160038, The roles and mechanisms of exosome of miR-30c-5p in chemotherapy resistant via vascular microenviroments regulation. 2019/01-2021/12,10万，under research, participant (second).

7) Zhejiang Provincial Science and Technology Planning Project, Provincial key Research and Development Plan, 2019C03010，The new diagnostic technique in ovarian cancer based on key problems guided, 201901-202212，2.5 million, under research, participant (third).

8) National Natural Science Foundation General project，81272861， The roles and mechanisms of MiR-375 in regulation of HPV16/18 virus oncoproteins, 2013/01－2016/12，700 thousand yuan, completed, participant.

Paper Publications：

1) Li Na, Chen Ruizhe, Wang Fenfen, Li Baohua, Preoperative serum creatinine as an independent prognostic biomarker in patients with early‑stage cervical adenocarcinoma，National Medical Journal of China，2022，102(26)，1987-1992.

2) Wang Fenfen, Bao Kechun, Cheng Xiaodong, Treatment for special pathological types of gestational trophoblastic neoplasia, Chinese Journal of Practical Gynecology and Obstetrics，2022，38(7)，697-702.

3) Wang L, Zhang J, Su Y, Maimaitiyiming Y, Yang S, Shen Z, Lin S, Shen S, Zhan G, Wang F, Hsu CH, Cheng X. Distinct Roles of m5C RNA Methyltransferase NSUN2 in Major Gynecologic Cancers. Front Oncol. 2022 Feb 25;12:786266. doi: 10.3389/fonc.2022.786266. PMID: 35280737; PMCID: PMC8916577. (2021 IF:5.738)

4) Cheng Xiaodong, Wang FenFen, Hot spots in diagnosis and treatment of recurrent ovarian cancer[J]. Zhejiang Medical Journal,2021,43(15):1593-1599.

5) Zhou L, Wang W, Wang F, Yang S, Hu J, Lu B, Pan Z, Ma Y, Zheng M, Zhou L, Lei S, Song P, Liu P, Lu W, Lu Y. Plasma-derived exosomal miR-15a-5p as a promising diagnostic biomarker for early detection of endometrial carcinoma. Mol Cancer. 2021 Mar 29;20(1):57. doi: 10.1186/s12943-021-01352-4. PMID: 33781255.(co-first author, 2021 IF:41.44)

6) Chen J, Wang FF, Zhang Y(Zhang, Yan)，Yang, B (Yang, Bin)，Ai, JH (Ai, Ji-hui)， Wang XY (Wang, Xin-yu)，Cheng XD (Cheng, Xiao-dong)， Li KZ (Li Ke-zhen)，Oncological and Reproductive Outcomes of Fertility-sparing Surgery in Women with Early-stage Epithelial Ovarian Carcinoma: A Multicenter Retrospective Study. Curr Med Sci. 2020;40(4):745-752. doi:10.1007/s11596-020-2239-4(co-first author, 2021 IF:2.640)

7) Wang Fenfen, Xie Xing.Etiology and risk factors of endometrial cancer [J]. Journal of Practical Obstetrics and Gynecology, 2020,36(06):401-403.

8) Wang Fenfen, Cheng Xiaodong, Fertility preserving treatment strategies for gestational trophoblastic tumors，Chinese Journal for Clinicians, 2020，48(4):408-412.

9) Wang Fenfen, Xie Xing. Progress in the treatment of ovarian cancer in 2020 [J]. Journal of Multidisciplinary Cancer Management (Electronic Version), 2021, 7(01): 34-37.

10) Baohua Li，Xuedong Guo，Na Li，Qin Chen，Junhua Shen，Xiaoxiu Huang，Genping Huang， Fenfen Wang， WNT1, a target of miR-34a, promotes cervical squamous cell carcinoma proliferation and invasion by induction of an E-P cadherin switch via the WNT/β-catenin pathway, Cellular Oncology,43(3)：489-503. https://doi.org/10.1007/s13402-020-00506-8，Jun， 2020. (corresponding author,2021 IF:7.05)

11) Wang F, Chen Q, Huang G, Guo X, Li N, Li Y, Li B. BKCa participates in E2 inducing endometrial adenocarcinoma by activating MEK/ERK pathway. BMC Cancer.2018 Nov 16;18(1):1128.(2021 IF:4.638)

12) Wang F, Li B, Xie X. The roles and clinical significance of  microRNAs in cervical cancer. Histol Histopathol. 2016 Feb;31(2):131-9. Review.(2021IF：2.13)

13) Wang F, Li Y, Zhou J, Xu J, Peng C, Ye F, Shen Y, Lu W, Wan X, Xie X*. miR-375 is down-regulated in squamous cervical cancer and inhibits cell migration and invasion via targeting transcription factor SP1. Am J Pathol，179(5)，2580-8，2011.(2021 IF:5.770)

14) Y. Li, F. Wang, J. Xu, F. Ye, Y. Shen, J. Zhou, W. Lu, X. Wan, D. Ma and X. Xie*，Progressive miRNA expression profiles in cervical carcinogenesis and identification of HPV related target genes for miR-29, Journal of Pathology, Aug;224(4):484-95, 2011.(co-first author, 2021 IF:9.883)

15) Tian Q, Li Y, Wang F, Li Y, Xu J, Shen Y, Ye F, Wang X, Cheng X, Chen Y, Wan X, Lu W, Xie X. MicroRNA detection in cervical exfoliated cells as a triage for human papillomavirus-positive women. J Natl Cancer Inst. 2014 Sep 4;106(9). pii: dju241. doi: 10.1093/jnci/dju241. Print 2014 Sep. PubMed PMID: 25190727.(co-first author,2021 IF:11.8)

16) Zheng M, Hou L, Ma Y, Zhou L, Wang F, Cheng B, Wang W, Lu B, Liu P, Lu W, Lu Y, Exosomal  let-7d-3p and miR-30d-5p as diagnostic biomarkers for non-invasive screening of cervical cancer and its precursors. Mol Cancer. 2019 Apr 2;18(1):76. doi:  10.1186/s12943 -019-0999-x. (2021 IF:41.4)

17) Zhang J, Wang F, Xu J, Wang X, Ye F, Xie X. Micro ribonucleic acid-93 promotes oncogenesis of cervical cancer by targeting RAB11 family interacting protein 1. J Obstet Gynaecol Res. 2016 Jun 8. doi: 10.1111/jog.13027. (2021 IF:1.697)

18) Huang, YongJie，Li, Yang，Wang, Fen F.，Lv, WeiGuo，Xie, Xing，Cheng, Xiaodong(*)，Over-Expressed miR-224 Promotes the Progression of Cervical Cancer via Targeting RASSF8，PLos One，2016.9.14，11(9)，SCI， (2021 IF:3.75)

19) Li, Baohua，Shi, Haiyan，Wang, Fenfen，Hong, Die，Lv, Weiguo，Xie, Xing，Cheng, Xiaodong(*)，Expression of E-, P- and N-Cadherin and Its Clinical Significance in Cervical Squamous Cell Carcinoma and Precancerous Lesions，Plos One，2016.5.25，11(5)，SCI, (2021 IF:3.75)

20) Xu, Junfen，Fang, Yifeng，Wang, Xinyu，Wang, Fenfen，Tian, Qifang，Li, Ying，Xie, Xing，Cheng, Xiaodong(*)，Lu, Weiguo(*)，CUL2 overexpression driven by CUL2/E2F1/miR-424 regulatory loop promotes HPV16 E7 induced cervical carcinogenesis，Oncotarget，2016.5.24，7(21)：31520~31533.

21) Hu, Dongxiao，Zhou, Jiansong，Wang, Fenfen，Shi, Haiyan，Li, Yang，Li, Baohua(*)，HPV-16 E6/E7 promotes cell migration and invasion in cervical cancer via regulating cadherin switch in vitro and in vivo，Archives of Gynecology and Obstetrics，2015.12.01，292(6)：1345~1354，SCI, (2021 IF:2.49)

22) Yang Li,  Xiaohong Wang, Ting Ni, Fenfen Wang, Weiguo Lu,b Jun Zhu, Xing Xie,  Zhi-Ming Zheng , Human Papillomavirus Type 58 Genome Variations and RNA Expression in Cervical Lesions. Journal of Virology, 2013 87(16), 9313–9322. (2021 IF:6.549)

23) Zhou J, Li B, Peng C, Wang F, Fu Z, Zhou C, Hong D, Ye F, Lü W, Xie X. Inhibition of cervical cancer cell growth in vitro and in vivo by lentiviral-vector mediated shRNA targeting the common promoter of HPV16 E6 and E7 oncogenes. Antiviral Res. 2013 May;98(2):305-13. doi: 10.1016/j.antiviral.2013.03.010. Epub 2013 Mar 21. PubMed PMID: 23523766. (2021 IF:10.103)

24) Yuanming Shen, Yang Li, Feng Ye, Fenfen Wang, Xiaoyun Wan, Weiguo Lu and Xing Xie*，Identification of miR-23a as a novel microRNA normalizer for relative quantification in human uterine cervical tissues.，Exp Mol Med.30;43(6): 358-66, 2011.(2021 IF:12.15)

25) Xu J, Li Y, Wang F, Wang X, Cheng B, Ye F, Xie X, Zhou C, Lu W. Suppressed miR-424 expression via upregulation of target gene Chk1 contributes to the progression of cervical cancer. Oncogene. 2013 Feb 21;32(8):976-87. doi: 10.1038/onc. 2012.121. Epub 2012 Apr 2. PubMed PMID: 22469983. (2021 IF:8.756)

26) Zhou J, Peng C, Li B, Wang F, Zhou C, Hong D, Ye F, Cheng X, Lü W, Xie X. Transcriptional gene silencing of HPV16 E6/E7 induces growth inhibition via apoptosis in vitro and in vivo. Gynecol Oncol. 2012 Feb;124(2):296-302. doi: 10.1016/j.ygyno.2011.10.028. Epub 2011 Nov 3. PubMed PMID: 22056554. (2021 IF:5.304)

27) Shen Y, Li Y, Ye F, Wang F, Lu W, Xie X*. Identification of suitable reference genes for measurement of gene expression in human cervical tissues. Anal Biochem. Oct 15;405(2):224-9.,2010.(2021 IF:3.19)

28) Wang FF, Chen HZ, Xie X, Ye F, Ye DF, Lü WG, Ding ZM. [Phosphorylation of signal transducer and activators of transcription 3 induced by vascular endothelial growth factor in ovarian carcinoma cell line in vitro].CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY. 2004 Jun;39(6):385-9. Chinese. PubMed PMID: 15312322.

29) Dou, Yuya，Zhang, Xiaodan，Li, Yang，Wang, Fenfen，Xie, Xing，Wang, Xinyu，Triage for management of cervical high-grade squamous intraepithelial lesion patients with positive margin by conization: a retrospective analysis，FRONTIERS OF MEDICINE，2017.6，11(2)：223~228，SCIE，(2021 IF:9.927)

30) A retrospective analysis on 1901 women with high grade cervical intraepithelial neoplasia by colposcopic biopsy, Zhang, Xiaodan，Dou, Yuya，Wang, Mateng，Li, Yang，Wang, Fenfen，Xie, Xing，Wang, Xinyu, EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY，2017.10，217：53~58 ; SCIE(2021 IF:2.83)