Education:

04/2014-03/2015 Medical Doctoral at the University of Lübeck Germany

09/2008-07/2012 Ph.D., specialized in Gynecologic Oncologist, Zhejiang University

09/2002-07/2005 Master of Medicine, specialized in Obstetrics and Gynecology,

Zhejiang University.

09/1997-07/2000 Bachelor of Medicine, School of Medicine, Zhejiang University.

Employment:

04/2014 until now. Deputy Director of Gynecologic Oncology department. The Women’s Hospital affiliated to School of Medicine, Zhejiang University

03/2014-03/2015 Visiting Scholar, Research Laboratory, Department of Gynecology & Obstetrics, University of Lübeck

12/2006-9/2014 Attending Fellow, The Women’s Hospital affiliated to School of Medicine, Zhejiang University

08/2005-12/2006 Resident Fellow, The Women’s Hospital affiliated to School of

Medicine, Zhejiang University

Research areas:

The mechanism of the occurrence and development of cervical cancer

The mechanism of drug resistance in ovarian cancer

Honors:

1. Research and development of new technology for cervical cancer screening and establishment and application of prevention and control system

Ministry of national education , China 2017-10-01

2. Zhejiang medical star [2020] No. 40.

Publications:

1. Xu J, Fang Y, Chen K, Li S, Tang S, Ren Y, Cen Y, Fei W, Zhang B, Shen Y, Lu W.Single-cell RNA sequencing reveals the tissue architecture in human high-grade serous ovarian cancer.Clin Cancer Res. 2022 Jun 80296.2022-1-28 （共同通迅）

2. Shen Y, Ren Y, Chen K, Cen Y, Zhang B, Lu W, Xu J.The impact of neoadjuvant chemotherapy on the tumor microenvironment in advanced high-grade serous carcinoma.Oncogenesis. 2022 Jul 30;11(1):43

3. Xu J, Shen Y, Wang C, Tang S, Hong S, Lu W, Xie X, Cheng X.Arsenic compound sensitizes homologous recombination proficient ovarian cancer to PARP inhibitors.Cell Death Discov. 2021 Sep 22;7(1):259.（共一）

4. Chen Z, Chu R, Shen Y, Yao Q, Chen J, Qin T, Li L, Chen G, Gao Q, Sun C, Song L, Li J, Liu P, Pan X, Li J, Zhu X, Zhang L, Qiao X, Ma D, Kong B, Song K.Evaluation of the prognostic value of lymphadenectomy for low-grade serous ovarian cancer: A case-control multicenter retrospective study.Transl Oncol. 2022 Jul 4;23:101476. （共一）

5. Shen Y, Tang S, Xu J, Xie X, Chen Z. Modified Intraperitoneal Chemotherapy Without Bevacizumab as a First-Line Therapy for Newly Diagnosed Advanced Epithelial Ovarian Cancer-Two Centers Experiences.Front Med (Lausanne). 2022 Mar 17;9:846352

6. Li J, Wang Y, Lu B, Lu W, Xie X, Shen Y. Gestational trophoblastic neoplasia with extrauterine metastasis but lacked uterine primary lesions: a single center experience and literature review.BMC Cancer. 2022 May 6;22(1):509. 

7. Shen Y, Liang Y, Cheng X, Lu W, Xie X, Wan X.Ovarianfibroma/fibrothecoma with elevated serum CA125 level: A cohort of 66 cases.Medicine (Baltimore). 2018 Aug;97(34):e11926.

8. Shen Y, Wan X, Xie X.A metastatic invasive mole arising from iatrogenic uterus perforation.BMC Cancer. 2017 Dec 20;17(1):876.

9. Shi Y, Li L, Hu Z, Li S, Wang S, Liu J, Wu C, He L, Zhou J, Li Z, Hu T, Chen Y, Jia Y, Wang S, Wu L, Cheng X, Yang Z, Yang R, Li X, Huang K, Zhang Q, Zhou H, Tang F, Chen Z, Shen J, Jiang J, Ding H, Xing H, Zhang S, Qu P, Song X, Lin Z, Deng D, Xi L, Lv W, Han X, Tao G, Yan L, Han Z, Li Z, Miao X, Pan S, Shen Y, Wang H, Liu D, Gong E, Li Z, Zhou L, Luan X, Wang C, Song Q, Wu S, Xu H, Shen J, Qiang F, Ma G, Liu L, Chen X, Liu J, Wu J, Shen Y, Wen Y, Chu M, Yu J, Hu X, Fan Y, He H, Jiang Y, Lei Z, Liu C, Chen J, Zhang Y, Yi C, Chen S, Li W, Wang D, Wang Z, Di W, Shen K, Lin D, Shen H, Feng Y, Xie X, Ma D. A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12. Nat Genet. 2013 ;45(8):918-22.

10. Wang F, Li Y, Zhou J, Xu J, Peng C, Ye F, Shen Y, Lu W, Wan X, Xie X. miR-375 is down-regulated in squamous cervical cancer and inhibits cell migration and invasion via targeting transcription factor SP1. Am J Pathol. 2011;179(5):2580-8.

11. Shen Y, Li Y, Ye F, Wang F, Wan X, Lu W, Xie X. Identification of miR-23a as a novel microRNA normalizer for relative quantification in human uterine cervical tissues. Exp Mol Med. 2011 Jun 30;43(6):358-66.

12. Li Y, Wang F, Xu J, Ye F, Shen Y, Zhou J, Lu W, Wan X, Ma D, Xie X.Progressive miRNA expression profiles in cervical carcinogenesis and identification of HPV-related target genes for miR-29. J Pathol. 2011;224(4):484-95.