Biography：

Dr. Li Yang is an associate chief physician and master supervisor at Women’s Hospital of Zhejiang University, School of Medicine. She was a graduate from a six-year English medical class from Shandong University School of Medicine in 2007 and received her PhD from Zhejiang University on gynecologic oncology in 2012. She joined Dr. Zhiming Zheng lab at National Cancer Institute/NIH from 04/2011 to 04/2012, and joined Dr. Sood K. Anil lab at MD Anderson Cancer Center from 06/2018 to 12/2019 as a visiting scientist. Due to her outstanding research results, she was invited by Professor Steven M. Frisch, the authority in the field of Anoikis research to participate in the compilation of Book “Anoikis: How the Extracellular Matrix Regulates Life-or-Death Decisions”.

In recent years, she continues her commitment to research during her busy clinical residency in Gynecologic Oncology, and successfully gains multiple research grants to fund her research, including National Natural Science Foundation of China (No. 81301687, 82072858) and Natural Science Foundation of Zhejiang Province (No. LQ13H160003, LY19H160038). She has more than 10 publications as the first or co-first author, such as Journal of Pathology, J Natl Cancer Inst., Oncogene, Journal of Virology, iScience, and Clin Transl Med. She was voted as a rising star in the medical field of Zhejiang Province in 2021 and serves as secretary and young member of the Obstetrics and Gynecology Branch of Zhejiang Medical Association, vice chairman of the Youth Committee of Zhejiang Cancer Association, and young member of the Gynecological Cancer Branch of Zhejiang Province.

Recent research grants as PIs:

1. The role and mechanism of chronic stress in anoikis of cervical cancer through HPV-YAP1-IGFBP2, supported by the National Natural Science Foundation of China, 2021/01-2024/12, ¥ 550,000

2. The engineering exosomes loaded with mir-92b-3p in anti-angiogenic therapy of ovarian cancer, supported by the Special Fund for Scientific Development of the Basic Scientific Research Foundation of Zhejiang University, 2021/01-2023/12, ¥450,000

3. Carcinogenic characteristics and mechanism of HPV58 gene in Chinese women, supported by the National Natural Science Foundation of China, 2014/01-2016/12, ¥ 230,000

4. The role and mechanism of exosome miR-30c-5p regulating vascular microenvironment in chemotherapy resistance of ovarian cancer, supported by the Natural Science Foundation of Zhejiang Province, 2019/01-2021/12, ¥ 90,000

5. The gene expression and carcinogenic mechanism of high risk HPV58 virus in Chinese women, supported by the Natural Science Foundation of Zhejiang Province, 2013/01-2015/12, ¥ 50,000

Research directions:

1. Early diagnosis and molecular-based treatment of endometrial cancer.

2. Early screening and diagnosis of gynecological malignant tumors.

Majors:

Gynaecology and Obstetrics

Publications

1. Wang J, Wang C, Li Y（Co-first）, Li M, Zhu T, Shen Z, Wang H, Lv W, Wang X, Cheng X, Xie X. Potential of peptide-engineered exosomes with overexpressed miR-92b-3p in anti-angiogenic therapy of ovarian cancer. Clin Transl Med. 2021 May;11(5):e425

2. Li Y, Yang S, Sadaoui NC, Hu W, Dasari SK, Mangala LS, Sun Y, Zhao S, Wang L, Liu Y, Ramondetta LM, Li K, Lu C, Kang Y, Cole SW, Lutgendorf SK, Sood AK. Sustained Adrenergic Activation of YAP1 Induces Anoikis Resistance in Cervical Cancer Cells. iScience. 2020 Jul 24;23(7):101289

3. Qifang Tian #, Yang Li#( Co-first), Fenfen Wang, Ying Li, Junfen Xu, Yuanming Shen, Feng Ye, Xinyu Wang, Xiaodong Cheng, Yaxia Chen, Xiaoyun Wan, Weiguo Lu, Xing Xie*. MicroRNA Detection in Cervical Exfoliated Cells as a Triage for Human Papillomavirus-Positive Women. J Natl Cancer Inst, 2014,106(9). pii: dju241. 

4. Yang Li, Xiaohong Wang, Ting Ni, Fenfen Wang, Weiguo Lu, Jun Zhu, Xing Xie, Zhi-Ming Zheng*. Human papillomavirus type 58 genome variations and RNA expression in cervical lesions. J Virol, 2013,87(16):9313-9322

5. Junfen Xu #, Yang Li #( Co-first), Fenfen Wang, Xinyu Wang, Bei Cheng, Feng Ye, Xing Xie, Caiyun Zhou, Weiguo Lu *. Suppressed miR-424 expression via upregulation of target gene Chk1 contributes to the progression of cervical cancer. Oncogene, 2013, 32 (8): 976-987

6. Yang Li, Fenfen Wang, Junfen Xu, Feng Ye, Yuanming Shen, Jiansong Zhou, Weiguo Lu, Xiaoyun Wan, Ding Ma and Xing Xie*. Progressive miRNA expression profiles in cervical carcinogenesis and identification of HPV related target genes for miR-29. J Pathol, 2011, 224 (4), 484-495

7. Book:

Yang Li, Shanshan Yang, Wei Hu, and Anil K. Sood. The Roles of Anoikis in Cervical Cancer. In: Steven M. Frisch, editor. Anoikis: How the Extracellular Matrix Regulates Life-or-Death Decisions. Springer Nature Switzerland AG 2021. p. 127-136