Education:

09/2004-06/2007 Zhejiang University, China

Ph.D. in Molecular Pathology

Supervisor: Professor Maode Lai

09/2000-06/2003 Zhejiang University, China

M.M. in Molecular Pathology

Supervisor: Professor Maode Lai

Professional Experience:

1.08/2022-present Director

Department of Surgical Pathology, the Affiliated Women’s Hospital, School of Medicine, Zhejiang University

2.02/2016-07/2022 Vice Director

Department of Surgical Pathology, the Affiliated Women’s Hospital, School of Medicine, Zhejiang University

3.10/2013-12/2013 Chinese Fellowship (Histopathology)

Department of Pathology & Laboratory Medicine, School of medicine, Indiana University & Purdue University Indiana (IUPUI), USA

Supervisor: Professor Liang Cheng

1.01/2013-present Attending Pathologist/Associate Professor

Department of Surgical Pathology, the Affiliated Women’s Hospital, School of Medicine, Zhejiang University

2.06/2011-12/2012 Attending Pathologist/Lecturer

Department of Surgical Pathology, the Affiliated Women’s Hospital, School of Medicine, Zhejiang University

3.08/2007-05/2011 Fellow/Lecturer (Histopathology) Department of Surgical Pathology, the Affiliated Women’s Hospital, School of Medicine, Zhejiang University

4.10/1999-01/2000 Chinese Fellowship (Cytopathology)

Department of Anatomical & Cellular Pathology, Prince Wales Hospital School of Medicine, Chinese University of Hong Kong, HKSAR, China

Supervisor: Professor Alexander Chang

1.09/1991-08/2004 Resident (cytopathology)

Department of Surgical Pathology, the Affiliated Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University

Professional & Research Interests:

2.Histopathology in the female genital tract and breast disease

3.Molecular Biology/Molecular Pathology

Recent Journal Articles in International Journals (*Corresponding Author):

1. Wu M, Qiu Q, Zhou Q, Li J, Yang J, Zheng C, Luo A, Li X, Zhang H, Cheng X, Lu W, Liu P#, Lu B#, Lu Y*. circFBXO7/miR-96-5p/MTSS1 axis is an important regulator in the Wnt signaling pathway in ovarian cancer. Mol Cancer. 2022;21(1):137. doi: 10.1186/s12943-022-01611-y. (#Co-corresponding Author)

2. Li J, Wang Y, Lu B, Lu W, Xie X, Shen Y*. Gestational trophoblastic neoplasia with extrauterine metastasis but lacked uterine primary lesions: a single center experience and literature review. BMC Cancer.  2022;22(1):509. doi: 10.1186/s12885-022-09620-2.

3. Zhou L, Qiu Q, Zhou Q, Li J, Yu M, Li K, Xu L, Ke X, Xu H, Lu B, Wang H, Lu W, Liu P, Lu Y. Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer. Nat Commun. 2022;13(1):2563. doi: 10.1038/s41467-022-30190-1.

4. Shi H, Shao Y, Zhang H, Ye L, Xu E, Lu B*.  Independent validation of distinct clinicopathological features and prognosis among usual-type, mucinous-type and gastric-type endocervical adenocarcinoma categorized by new WHO classification Pathology. 2022;S0031-3025(22)00084-8.

5. Shao Y, Lu B*.The emerging roles of circular RNAs in vessel co-option and vasculogenic mimicry: clinical insights for anti-angiogenic therapy in cancers. Cancer Metastasis Rev. 2022;41(1):173-191. doi: 10.1007/s10555-021-10000-8.

6. Shi H,Ye L, Lu W, Lu B*. Grading of endocervical adenocarcinoma: a novel prognostic system based on tumor budding and cell cluster size. Mod Pathol. 2022;35(4):524-532. doi: 10.1038/s41379-021-00936-1.

7. Lu B*, Shi H, Shao Y, Xu J. Ovarian metastasis of cervical gastric-type adenocarcinoma: a clinicopathological analysis of 12 cases. Int J Gynecol Pathol.  2022;41(4):356-365. doi: 10.1097/PGP.0000000000000815

8. Qian X, Yang J, Qiu Q, Li X, Jiang C, Li J, Dong L, Ying K, Lu B, Chen E, Liu P#, Lu Y*. LCAT3, a novel m6A-regulated long non-coding RNA, plays an oncogenic role in lung cancer via binding with FUBP1 to activate c-MYC. J Hematol Oncol. 2021;14(1):112. doi: 10.1186/s13045-021-01123-0.

9. Zhang H, He P, Zhou Q, Lu Y, Lu B*. The potential oncogenic and MLN4924-resistant effects of CSN5 on cervical cancer cells. Cancer Cell Int. 2021;21(1):369. doi: 10.1186/s12935-021-02078-5.

10. Sun X, Yi J, Yang J, Han Y, Qian X, Liu Y, Li J, Lu B, Zhang J, Pan X, Liu Y, Liang M, Chen E, Liu P#, Lu Y*. An integrated epigenomic-transcriptomic landscape of lung cancer reveals novel methylation driver genes of diagnostic and therapeutic relevance. Theranostics. 2021;11(11):5346-5364. doi: 10.7150/thno.58385.

11. Zhou L, Wang W, Wang F, Yang S, Hu J, Lu B, Pan Z, Ma Y, Zheng M, Zhou L, Lei S, Song P, Liu P, Lu W, Lu Y*. Plasma-derived exosomal miR-15a-5p as a promising diagnostic biomarker for early detection of endometrial carcinoma. Mol Cancer. 2021;20(1):57. doi: 10.1186/s12943-021-01352-4.

12. Qiu Q, Zhou Q, Luo A, Li X, Li K, Li W, Yu M, Amanullah M, Lu B, Lu W, Liu P, Lu Y*. Integrated analysis of virus and host transcriptomes in cervical cancer in Asian and Western populations. Genomics. 2021;113(3):1554-1564. doi: 10.1016/j.ygeno.2021.03.029

13. Shi H, Shao Y, Lu W#, Lu B*. An analysis of HER2 amplification in cervical adenocarcinoma: correlation with clinical outcomes and the International Endocervical Adenocarcinoma Criteria and Classification J Pathol Clin Res. 2021;7(1):86-95. doi: 10.1002/cjp2.184. 

14. Sun X, Yang J, Yu M, Yao D, Zhou L, Li X, Qiu Q, Lin W, Lu B, Chen E, Wang P, Chen W, Tao S, Xu H, Williams A, Liu Y, Pan X, Cowley AW Jr, Lu W, Liang M, Liu P#, Lu Y*. Global identification and characterization of tRNA-derived RNA fragment landscapes across human cancers. NAR Cancer. 2020;2(4):zcaa031. doi: 10.1093/narcan/zcaa031.

15. Zhang H, Lu B*. The Roles of ceRNAs-Mediated Autophagy in Cancer Chemoresistance and Metastasis. Cancers (Basel). 2020;12(10):2926. doi: 10.3390/cancers12102926.

16. Shao Y, Lu B*. The crosstalk between circular RNAs and the tumor microenvironment in cancer metastasis. Cancer Cell Int. 2020;20:448. doi: 10.1186/s12935-020-01532-0.

17. Lu B*, Chen J, Shao Y, Shi H. Two cases of ZC3H7B-BCOR high grade endometrial stromal sarcoma with an extension on its morphological features. Pathology. 2020;S0031-3025(20)30860-6. doi: 10.1016/j.pathol.2020.05.007. (Online ahead of print)

18. Zhang H, Lu B*. microRNAs as biomarkers of ovarian cancer. Expert Rev Anticancer Ther. 2020;20(5):373-385.

19. Ma Y, Wang S, Liu Q, Lu B*. A clinicopathological and molecular analysis in uterine leiomyomas and concurrent/metachronous peritoneal nodules: New insights into disseminated peritoneal leiomyomatosis. Pathol Res Pract. 2020;216(5):152938.

20. Shao Y, Liu Q, Shi H, Lu B*. Ovarian mucinous tumors with mural nodules: immunohistochemical and molecular analysis of 3 cases. Diagn Pathol. 2020;15(1):35. doi: 10.1186/s13000-020-00956-6.

21. Lu B*, Liu Q, Tang L, Ma Y, Shi H. Intravenous leiomyomatosis: molecular analysis of 17 cases. Pathology. 2020;52(2):213-217.

22. Shi H, Shao Y, Liu Q, Wang S, Lu W, Lu B*. A clinicopathological and molecular analysis of cervical carcinomas with basaloid features. Histopathology. 2020;76(2):283-295. doi: 10.1111/his.13968.

23. Yang J, Qiu Q, Qian X, Yi J, Jiao Y, Yu M, Li X, Li J, Mi C, Zhang J, Lu B, Chen E, Liu P#, Lu Y*. Long noncoding RNA LCAT1 functions as a ceRNA to regulate RAC1 function by sponging miR-4715-5p in lung cancer. Mol Cancer. 2019;18(1):171. doi: 10.1186/s12943-019-1107-y.

24. Jiao Y, Lu B*. Poorly differentiated mucinous carcinoma with signet ring cells in an ovarian endometriotic cyst: a case report. Diagn Pathol. 2019;14:73.

25. Liu Q, Wu Q, Yu M, Shi H, Lu B*. Emerging relationships between papillary proliferation of the endometrium and endometrial carcinoma: evidence from an immunohistochemical and molecular analysis. Virchows Arch. 2019;475(2), 201-209.

26. Zhang L, Zhou Q, Qiu Q, Hou L, Wu M, Li J, Li X, Lu B, Cheng X, Liu P, Lu W, Lu Y*. CircPLEKHM3 acts as a tumor suppressor through regulation of the miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis in ovarian cancer. Mol Cancer. 2019;18(1):144. doi: 10.1186/s12943-019-1080-5.

27. Zheng M, Hou L, Ma Y, Zhou L, Wang F, Cheng B, Wang W, Lu B, Liu P, Lu W, Lu Y*. Exosomal let-7d-3p and miR-30d-5p as diagnostic biomarkers for non-invasive screening of cervical cancer and its precursors Mol Cancer. 2019 2;18(1):76.

28. Lu B*, Yu M, Shi H, Chen Q. Atypical polypoid adenomyoma of the uterus: A reappraisal of the clinicopathological and immunohistochemical features. Pathol Res Pract. 2019;215(4):766-77.

29. Lu B*, Teng X, Fu G, Bao L, Tang J, Shi H, Lu W, Lu Y#. Analysis of PD-L1 expression in trophoblastic tissues and tumors.Hum Pathol. 2019;84(1):202-212  (#Co-corresponding Author)

30. Lu B*, Shi H. An In-Depth Look at Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT): Clinical Implications from Recent Molecular Findings. J Cancer. 2019;10(1):223-237.

31. Liang Y*, Lü B, Zhou C. Cervical Adenoid Basal Carcinoma: Clinicopathologic Features of 9 Cases With Reference to CK17 and Ki-67 Expression. J Low Genit Tract Dis. 2019;23(1):77-81.

32. Liu HY, Zhou L, Zheng MY, Huang J, Wan S, Zhu A, Zhang M, Dong A, Hou L, Li J, Xu H, Lu B, Lu W, Liu P, Lu Y*. Diagnostic and clinical utility of whole genome sequencing in a cohort of undiagnosed Chinese families with rare diseases. Sci Rep. 2019;9(1):19365.

Journals Reviewers:

1.BJOG: An International Journal of Obstetrics & Gynaecology

2.Acta Histochemica

3.European Journal of Obstetrics & Gynecology and Reproductive Biology

4.Chinese Medical Journal

5.Diagnostic Pathology

6.Pathology - Research and Practice

7.Cancer Immunology, Immunotherapy

8.Plos One

9.BMJ open

10.Journal of Clinical Pathology

11.OncoTargets & Therapy

12.The Journal of Obstetrics & Gynaecology Research

Journal Editors

Chinese Journal of Pathology (Guest Editor)

Foundations:

1. The role of long non-coding RNA SFTA1P-IFIT3-CSN5 axis in the pathogenesis of cervical cancer. Natural & Science Foundation of China, 2018-2021. 540,000RMB (Principal Investigator)

2. Identification of biomarkers and preliminary functional analysis in ovarian cancer metastasis. Zhejiang Natural & Science Foundation, 2011-2013. 60,000RMB (Principal Investigator)

3. The mechanism of leptin regulating IGFBP7 expression in endometrial carcinoma. Natural & Science Foundation of China, 2014-2017. 700,000RMB (Principal Investigator)

4. Regulating of IGFBP-rP1 expression by progesterone in endometrial carcinoma. Natural & Science Foundation of China, 2013-2015. 1,000,000RMB (Co-investigator, Rank 2/7)

5. The structural basis of IGFBP-rP1 functions in colorectal carcinoma. Natural & Science Foundation of China, 2012-2014. (Co-investigator, Rank 2/8)

6. Prevention and early intervention on metabolic syndrome. Key science and project support project of the 11th of five year plan by National Bureau of Science & Technology, 2010-2013. 1,000,000RMB (Co-investigator)

Books and Chapters

1. Chapter 17: Disease of productive system. In The “12th Five-years” Textbooks for Graduate Students: Pathology. Mode Lai, Ziyong Liang, Xinxai Tian, Yilei Li (Eds). People’s Health Press, 2014.

2. Chapter 17: Disease of productive system. In The “13th Five-years” Textbooks for Graduate Students: Pathology. Mode Lai, Yilei Li, Zhiyong Liang (Eds). People’s Health Press, 2021.

Awards and Honors:

1. Maode Lai, Lina Shao, Yuwei Zhang, Minjie Luo, Yiming Zhu, Qiong Huang, Jian Chen, Hao Zhang, Xuemei Gu, Bingjian Lü. The First Prize of Science And Technology, Zhejiang Province, China 2005.”

2. Maode Lai, Bingjian Lü, Enping Xu, Fangying Xu, Wenijng Ruan, Qiong Huang, Jian Chen, Jie Lin, Xiaoming Xing, Yiming Zhu. The First Prize of Science And Technology, Zhejiang Province, China 2012.

3. Tianxiang Liu Award for Excellent Young Doctors, 2012, Women’s Hospital, the Affiliated Women’s Hospital, School of Medicine, Zhejiang University

4. Guanghua Award, Zhejiang University, China 09/2005

5. Zhangshi Award, Zhejiang University, China 09/2006