Biography:

Dr. Zhang is now a professor of Women’s Hospital, Zhejiang University School of Medicine as well as the director of general gynecology. Dr. Zhang has been involved in translational and clinical research to develop novel treatments for endometriosis and adenomyosis, such as double-flap adenomyomectomy for adenomyosis, and non-stapler segmental resection for deep endometriosis. A new trick for an old dog- mifepristone for adenomyosis treatment, A new self-designed rectal probe for the surgical treatment of deep endometriosis, etc. His basic research mainly focused on the mechanisms of endometriosis-associated pain, and was supported by the grants of the National Key R&D Program of China, the National Natural Science Foundation of China. He is a regular contributor to peer reviewed scientific journals including Human Reproduction, Fertility and Sterility, Obstetrics & Gynecology, etc. He has published over 100 scientific articles, and authored a book of Adenomyosis published by people's Health Press in 2018.

Published aricles [Zhang X (XM) as first author or corresponding author ]:

1. Lin Q, Li T, Ding S, Yu Q, Zhang X. Anemia associated platelets and plasma prothrombin time increase in patients with adenomyosis. J Clin Med. 2022 Jul 28;11(15):4382. doi: 10.3390/jcm11154382.

2. Xu X, Chen Y, Yu Q, Wang J, Xu P, Zhu L, Xu Q, Zhang J, Cui S, Yu K, Li T, Guo X, Zhang X. The presence of living endometrial cells in ovarian endometriotic cyst fluid may contribute to the recurrence of endometriosis after surgical excision of endometriomas. J Ovarian Res. 2022;15(1):89.

3. Liu Y, Wang J, Zhang X. An update on the multifaceted role of NF-kappaB in endometriosis. Int J Biol Sci. 2022; 18(11): 4400-4413.

4. Zhao M, Zhang M, Yu Q, Fei W, Li T, Zhu L, Yao Y, Zheng C and Zhang X. Hyaluronic Acid-Modified Nanoplatforms as a Vector for Targeted Delivery of Autophagy-Related Gene to the Endometriotic Lesions in Mice. Front Bioeng Biotechnol. 2022; 10:918368.

5. Zhou Y, Shen L, Wang Y, Yang M, Chen Z, Zhang X. Long term pregnancy outcomes of patients with diffuse adenomyosis after double-flap adenomyomectomy. J. Clin. Med. 2022; 11(12):3489.

6. Xu P, Wang J, Zhang Y, Zhu L, Zhang X. Factors affecting the postoperative bowel function and recurrence of surgery for intestinal deep endometriosis. Front. Surg. 2022; 9:914661.

7. Yin M, Zhai L, Wang J, Yu Q, Li T, Xu X, Guo X, Mao X, Zhou J and Zhang X. (2022) Comprehensive Analysis of RNA-Seq in Endometriosis Reveals Competing Endogenous RNA Network Composed of circRNA, lncRNA and mRNA. Front Genet . 2022;13:828238.

8. Zhu L, Guan Z, Huang Y, Hua K, Ma L, Zhang J, Yang D, Perrot V, Li H, Zhang X. The efficacy and safety of triptorelin-therapy following conservative surgery for deep infiltrating endometriosis: A multicenter, prospective, non-interventional study in China. Medicine (Baltimore).2022;101(5):e28766.

9. Sun M, Xu P, Zou G, Wang J, Zhu L, Zhang X. Extrinsic Adenomyosis Is Associated With Postoperative Recurrence of Ovarian Endometrioma. Front Med (Lausanne). 2022;8:815628.

10. Wang J, Xu P, Yang X, Yu Q, Xu X, Zou G, Zhang X. Association of Myometrial Invasion With Lymphovascular Space Invasion, Lymph Node Metastasis, Recurrence, and Overall Survival in Endometrial Cancer: A Meta-Analysis of 79 Studies With 68,870 Patients. Front Oncol. 2021;11:762329.

11. Yu Q, Wang J, Li T, Xu X, Guo X, Ding S, Zhu L, Zou G, Chen Y, Zhang X. RON Mediates Tumor-Promoting Effects in Endometrial Adenocarcinoma. Biomed Res Int. 2021; 2021:2282916.

12. Guo X, Xu X, Li T, Yu Q, Wang J, Chen Y, Ding S, Zhu L, Zou G, Zhang X. (2021) NLRP3 inflammasome activation of mast cells by estrogen via the nuclear-initiated signaling pathway contributes to the development of endometriosis. Front Immunol. 2021;12:749979.

13. Chen B, Zhu L, Yang X, Wang W, Zhang X. Endometriotic Lesions on Uterine Scar. J Minim Invasive Gynecol. 2021 Aug;28(8):1438-1439.

14. Sun W, Hua K, Hong L, Zhang J, Hao M, Wang J, Zhang J, Perrot V, Li H, Zhang X. Symptom control after different duration of triptorelin treatment following conservative surgery for deep infiltrating endometriosis: Post-hoc analysis of a multicentre, prospective, real-world study. Medicine (Baltimore). 2021 Jul 30;100(30):e26753.

15. Zou G, Wang J, Xu X, Xu P, Zhu L, Yu Q, Peng Y, Guo X, Li T, Zhang X. Cell subtypes and immune dysfunction in peritoneal fluid of endometriosis revealed by single-cell RNA-sequencing. https://doi.org/10.1186/s13578-021-00613-5. Cell Biosci. 2021 May 26; 11(1):98. 

16. Ying X, Che X, Wang J, Zou G, Yu Q, Zhang X. CDK1 serves as a novel therapeutic target for endometrioid endometrial cancer. J Cancer 2021; 12(8):2206-2215. doi:10.7150/jca.51139. 

17. Yu Q, Wang J, Li T, Guo X, Ding S, Che X, Zhu L, Peng Y, Xu X, Zou G, Zhang X. Recepteur d'origine nantais contributes to the development of endometriosis via promoting epithelial‐mesenchymal transition of a endometrial epithelial cells. J Cell Mol Med. 2021; 25(3):1601-1612.  

18. Ding S, Guo X, Zhu L, Wang J, Li T, Yu Q, Zhang X. Netrin-1 participates in endometriosis-associated pain. Ann Transl Med. 2021; 9(1):29.

19. Chen S, Wang J, Sun W, Zhu L, He J, Zhang X. Efficacy of the levonorgestrel-releasing intrauterine device is associated with different subtypes of adenomyosis: a retrospective study. Ann Transl Med 2020; 8 (21):1356. | http://dx.doi.org/10.21037/atm-20-3420  

20. Li T, Wang J, Guo X, Yu Q, Ding S, Xu X, Peng Y, Zhu L, Zou G, Zhang X. Possible involvement of crosstalk between endometrial cells and mast cells in the development of endometriosis via CCL8/CCR1. Biomedicine & Pharmacotherapy 129 (2020) 110476. 

21. Ding S, Yu Q, Wang J, Zhu L, Li T, Guo X, Zhang X. Activation of ATF3/AP-1 signaling pathway is required for P2X3-induced endometriosis pain. Hum Reprod. 2020;35(5):1130-1144.

22. Che X, Wang J, He J, Guo X, Li T, Zhang X. The new application of mifepristone in the relief of adenomyosis-caused dysmenorrhea. Int J Med Sci. 2020; 17(2):224-233.

23. Che X, Wang J, He J, Yu Q, Sun W, Chen S, Zou G, Li T, Guo X, Zhang X. A new trick for an old dog: The application of mifepristone in the treatment of adenomyosis. J Cell Mol Med. 2020; 24(2):1724–1737.

24. Zhou Y, Chen ZY, Zhang XM. Giant exophytic cystic adenomyosis with a levonorgestrel containing intrauterine device out of the uterine cavity after uterine myomectomy: A case report. World J Clin Cases. 2020;8(1):188-193.

25. Guo X, Ding S, Li T, Wang J, Yu Q, Zhu L, Xu X, Zou G, Peng Y, Zhang X. Macrophage-derived netrin-1 is critical for neuroangiogenesis in endometriosis, Int J Biol Macromol. 2020; 148:226-237.

26. Zou G, Xu P, Zhu L, Ding S, Zhang X. Comparison of subsequent pregnancy outcomes after surgery for adnexal masses performed in the first and second trimester of pregnancy. Int J Gynaecol Obstet. Int J Gynecol Obstet 2020; 148: 305–309.

27. Ding S, Lin Q, Zhu T, Li T, Zhu L, Wang J, Zhang X. Is there a correlation between inflammatory markers and coagulation parameters in women with advanced ovarian endometriosis? BMC Women's Health. 2019, 19(1):169.

28. Zhao MD, Li JQ, Chen FY, Dong W, Wen LJ, Fei WD, Zhang X, Yang PL, Zhang XM, Zheng CH. Co-Delivery of Curcumin and Paclitaxel by “Core-Shell” Targeting Amphiphilic Copolymer to Reverse Resistance in the Treatment of Ovarian Cancer. Int J of Nanomedicine. 2019:14; 9453–9467.

29. Baboo K, Chen Z, Zhang X. Role of Oxidative Stress and Antioxidant Therapies in Endometriosis. Reprod Dev Med, 2019,3(3): 170-176.

30. Zhu L, Chen S, Che X, Xu P, Huang X, Zhang X. Comparisons of the efficacy and recurrence of adenomyomectomy for severe uterine diffuse adenomyosis via laparotomy versus laparoscopy: a long-term result in a single institution. J Pain Res. 2019 Jun 27; 12:1917-1924.

31. Zhu TH, Zou G, Ding SJ, Li TT, Zhu LB, Wang JZ, Yao YX, Zhang XM. Mast cell stabilizer ketotifen reduces hyperalgesia in a rodent model of surgically induced endometriosis. J Pain Res. 2019 Apr 29; 12:1359-1369.

32. Dai Y, Zhang X, Xue M, Zhou Y, Sun P, Leng J. Not Having Been Breastfed May Protect Chinese Women From Developing Deep Infiltrating Endometriosis: Results From Subgroup Analyses of the FEELING Study. Reprod Sci. 2019 Aug;26(8):1158-1167.

33. Dai Y, Zhou Y, Zhang X, Xue M, Sun P, Leng J, Chapron C. Factors associated with deep infiltrating endometriosis versus ovarian endometrioma in China: a subgroup analysis from the FEELING study. BMC Womens Health. 2018 Dec 22;18(1):205.

34. Ding S, Zhu T, Tian Y, Xu P, Chen Z, Huang X, Zhang X. Role of Brain-Derived Neurotrophic Factor in Endometriosis Pain. Reprod Sci. 2018 Jul;25(7):1045-1057.

35. Zhu T, Ding S, Li T, Zhu L, Huang X, Zhang X. Estrogen is an important mediator of mast cell activation in ovarian endometriomas. Reproduction. 2018 Jan;155(1):73-83.

36. Yuan M, Ding S, Meng T, Lu B, Shao S, Zhang X, Yuan H, Hu F. Effect of A-317491 delivered by glycolipid-like polymer micelles on endometriosis pain. Int J Nanomedicine. 2017:12 8171–8183.

37. Ding S, Zhu L, Tian Y, Zhu T, Huang X, Zhang X. P2X3 receptor involvement in endometriosis pain via ERK signaling pathway. PLoS One. 2017 Sep 12;12(9):e0184647. doi: 10.1371/journal.pone.0184647. eCollection 2017.

38. Xu P, Ding S, Zhu L, Le F, Huang X, Tian Y, Zhang X. Elevated RON protein expression in endometriosis and disease-associated ovarian cancers. Arch Gynecol Obstet. 2017 Mar;295(3):631-639.

39. Li X, Shen B, Chen Q, Zhang X, Ye Y, Wang F, Zhang X. Antitumor effects of cecropin B-LHRH' on drug-resistant ovarian and endometrial cancer cells. BMC Cancer. 2016; 16(1):251.

40. Zhang J., Zhu L., Huang X., Xu P., Chen Z., Huang Q., Zhang X. Mitochondrial DNA haplogroup R confers a genetic risk factor for intrauterine adhesion in Han women population. Gynecol Obstet Invest. 2016;81(3):238-43.  

41. Chapron C, Lang JH, Leng JH, Zhou Y, Zhang X, Xue M, Popov A, Romanov V, Maisonobe P, Cabri P. Factors and Regional Differences Associated with Endometriosis: A Multi-Country, Case-Control Study. Adv Ther. 2016 Aug;33(8):1385-407.

42. Huang X, Huang Q, Chen S, Zhang J, Lin K, Zhang X. Efficacy of laparoscopic adenomyomectomy using double-flap method for diffuse uterine adenomyosis. BMC Womens Health. 2015 Dec; 15(1):182. 

43. Zhang XM, Huang X, Xu H, Quinn MJ. Altered innervation of the fallopian tube in adenomyosis. J Obstet Gynaecol.  2015 Apr; 35(3):319-20.

44. Che X, Liu X, Zhang X, Quinn M. Abnormal innervation of narrowed, uterine spiral arterioles in early pregnancy. J Obstet Gynaecol. 2014:35(1):88-9. 

45. Zhang X, Huang X, Xu H, Quinn M. Altered innervation of the fallopian tube in ectopic pregnancy. J Obstet Gynaecol. 2014 Aug; 34(6):531-2.

46. Zhu L, Huang Q, Huang X, Zhang J, Xu H, Zhang X. Decreased nerve fibers in the oviduct isthmus of women with endometriosis. Acta Histochem.  2014 Jun;116(5):871-7.  

47. Sun Y, Zhu L, Huang X, Zhou C, Zhang X. Immunohistochemical localization of nerve fibers in the pseudocapsule of fibroids. Eur J Histochem. 2014 May 8; 58(2):2249. 

48. Xu H, Yang Y, Caiyun Zhou C, Huang X, Lin J, Zhang X. Increased endometrial expression of CC-chemokine receptor-1 in women with adenomyosis. Histol Histopathol. 2014 Sep; 29(9):1153-60. 

49. Che X, Huang X, Zhang J, Xu H, Zhang X. Is nerve-sparing surgery suitable for deeply infiltrating endometriosis? Eur J Obstet Gynecol Reprod Biol. 2014 April; 175:87-91. 

50. Wang P, Zhu L, Zhang X. The role of placental protein 14 in the pathogenesis of endometriosis. Reprod Sci. 2013; 20 (12):.1465-1470.

51. Zhu L, Chen JX, Sun YM, Huang XF, Xu H, Zhang X. Loss of nerve fibers in the oviduct isthmus in women with hydrosalpinx. Acta Histochem. 2013; 115(6)609-615.

52. Feng C, Chen ZY, Zhang J, Xu H, Zhang XM, Huang XF. Clinical utility of serum reproductive hormones for the early diagnosis of ectopic pregnancy in the first trimester. J Obstet Gynaecol Res. 2013; 39(2):528-35.

53. Yang Y, Zhang X, Zhou C, Huang X, Lin J, Xu H. Elevated immunoreactivity of RANTES and CCR1 correlate with the severity of stages and dysmenorrhea in women with deep infiltrating endometriosis. Acta Histochem. 2013; 115(5):434-9. .

54. Fu G, Che X, Sun Y, Huang X, Xu H, Zhou C, Zhang X. Pigment epithelial-derived factor expression in endometriotic lesions in a rat model of endometriosis. Acta histochemica. 2013；115(4): 301-307.  

55. Zhang X, Huang X, Xu H, Quinn M. Endometriosis: a consequence of varying injuries to pelvic autonomic nerves. Fertil Steril. 2012; 98(6):e29. 

56. Zhang X, Xu H, Zhang X, Zhou C, Huang X. Persistent endometriosis of the right inferior hypogastric nerve.  J Obstet & Gynaecol. 2012, Vol. 32, No. 8, Pages 813-813.

57. Sun Y, Che X, Zhu L, Zhao M, Fu G, Huang X, Xu H, Hu F, Zhang X. Pigment epithelium derived factor inhibits the growth of human endometrial implants in nude mice and of ovarian endometriotic stromal cells in vitro. PLoS ONE 2012; 7(9): e45223.  

58. Huang X, Chen L, Fu G, Xu H, Zhang X. Decreased expression of pigment epithelium-derived factor and increased microvascular density in ovarian endometriotic lesions in women with endometriosis. Eur J Obstet Gynecol Reprod Biol. 2012 Nov; 165 (1):104-109.  

59. Chen L, Fan R, Huang X, Xu H, Zhang X. Reduced Levels of Serum Pigment Epithelium-Derived Factor in Women With Endometriosis. Reprod Sci. 2012; 19(1):64-69.  

60. Zhao MD, Sun YM, Fu GF, Du YZ, Chen FY, Yuan H, Zheng CH, Zhang XM, Hu FQ. Gene therapy of endometriosis introduced by polymeric micelles with glycolipid-like structure. Biomaterials. 2012 Jan;33 (2):634-43. [通信作者].

61. Fan R, Qiu L, Huang X, Chen Z, Xu H, Zhou C, Zhang X. Increased Nerve Fibers in Placental bed Myometrium in Women with Preeclampsia. Reprod Sci. 2011; 18 (12): 1262-1266.  

62. Chen L, Fan R, Huang X, Xu H, Zhang X. Decreased concentrations of pigment epithelium-derived factor in peritoneal fluid of patients with endometriosis. Fertil Steril. 2011 Apr;95(5):1798-800. 

63. Lasmar RB, Xinmei Z（hang）, Indman PD, Celeste RK, Di Spiezio Sardo A. Feasibility of a new system of classification of submucous myomas: a multicenter study. Fertil Steril. 2011 May;95(6):2073-7.

64. Zhang X, Lu B, Huang X, Xu H, Zhou C, Lin J. Innervation of endometrium and myometrium in women with painful adenomyosis and uterine fibroids. Fertil Steril. 2010;94(2):730-7.  

65. Zhang X, Qi C, Lin J. Enhanced expressions of matrix metalloproteinase (MMP)-2 and -9, vascular endothelial growth factors (VEGF), and increased microvascular density in endometrial hyperplasia of women with anovulatory dysfunctional uterine bleeding. Fertil Steril. 2010 May 1;93 (7):2362-7.

66. Ruan F, Lin J, Wu RJ, Xu KH, Zhang XM, Zhou CY, Huang XF. Phosphatase of regenerating liver-3: a novel and promising marker in human endometriosis. Fertil Steril. 2010;94(6):1980-4.

67. Zhang X, Yao H, Huang X, Lu B, Xu H, Zhou C. Nerve fibers in ovarian endometriotic lesions in women with ovarian endometriosis. Hum Reprod. 2010 Feb;25(2):392-7.  

68. Zhang X, Lu B, Huang X, Xu H, Zhou C, Lin J. Endometrial nerve fibres in women with endometriosis, adenomyosis and uterine fibroids. Fertil Steril. 2009; 92(5):1799-801. 

69. Lin K Zhu X, Hong Xu, Liang Z, Zhang X. Reproductive outcome following resectoscope metroplasty in women having a complete uterine septum with double cervix and vagina. Int J Gynaecol Obstet. 2009 Apr; 105(1):25-8.

70. Zhang X, Yuan H, Deng L, Hu F, Ma J, Lin J. Evaluation of the efficacy of a danazol-loaded intrauterine contraceptive device on adenomyosis in an ICR mouse model. Hum Reprod. 2008; 23(9): 2024–2030. 

71. Zhang X, Wen J, Deng L, Lin J. (2007) Decreased levels of peritoneal interleukin-1 receptor antagonist in patients with endometriosis and the disease-related dysmenorrhoea. Fertil & Steril. 2007 Sep;88(3):594-9.

72. Zhang X, Hei P, Deng L, Lin J. (2007) IL-10 gene promoter polymorphisms and their protein production in the peritoneal fluid in patients with endometriosis. Mol Hum Reprod, 2007 Feb;13(2):135-140.

73. Lin J, Zhang X, Deng L, Fang Q, Qian Y. Decreased peritoneal concentrations of interleukin-15 in women with advanced stage endometriosis. European Journal of Obstetrics & Gynecology and Reproductive Biology, 2006; 129 (12):169-173.

74. Zhang X, Xu H, Lin L, et al. Peritoneal fluid concentrations of interleukin-17 correlate with the severity of endometriosis and infertility of this disorder. BJOG., 2005; 112(8):1153-1155.

75. Zhang X, Lin,J Deng L. Peritoneal and serum IL-16 concentrations in women with endometriosis.  Acta Obstetricia et Gynecologica Scandinavica, 2005;84(3):297-299.

76. Zhang X, Liu X, Fang H. Interstitial pregnancy and transcervical curettage. Obstet.  Gynecol., 2004;104 (supple1):1193-1195.

77. Zhang X, Lin J, Deng L. Decreased levels of IL-18 in peritoneal fluid but not in serum of women with endometriosis. Fertil. Steril., 2004;81(5):1229-1234. 

78. Lin J, Zhang X, chen Y. Mutagen Sensitivity as a Susceptibility Marker for Endometriosis. Hum. Reprod., 2003; 18(9):2052-2057.

79. Lin J, Zhang X, Qian Y, et al.  Glutathione S- transferase M1 and T1 genotypes and endometriosis risk: a case-controlled study. Chin. Med. J. 2003; 116(11):777-780.

80. Lin J, Zhang X, Xu K. Application of ultrasonic scalpel in gynecologic operative laparoscopy.  Chin. Med. J.,  2001;114(9):1283-1285.

Schabath MB, Spitz MR, Zhang X, Delclos GL, Wu X. Genetic variants of myeloperoxidase and lung cancer risk. Carcinogenesis, 2000;21(12):1163-1166.