个人简历

2007年毕业于华中科技大学，获医学博士学位。2007年始在浙江大学医学院附属妇产科医院从事临床、科研工作。2015-2017年作为访问学者在美国国立健康研究院进行研修，主要从事卵巢癌药物筛选方面的研究。至今发表论文10余篇，主持国家自然科学基金3项。

主持课题

脚手架蛋白NEDD9在宫颈癌细胞衰老中的作用及其分子机制（国家自然科学基金）

脚手架蛋白NEDD9调节TGF-β在宫颈癌细胞上皮间质转化中的作用及其分子机制（国家自然科学基金）

质子泵抑制剂调节mTOR信号通路介导的自噬在卵巢癌顺铂耐药中的机制研究（国家自然科学基金）

研究方向

妇科肿瘤

代表论文

1. Wu Q, Wang L, Zhao X, Tian Q, Wang F, Sima N, Qiu L, Lu W, Xie X, Wang X, Cheng X. The Value of MicroRNA-375 Detection for Triaging Primary Human Papillomavirus Positive Women: A Cross-Sectional Study in a General Population. Front Oncol. 2021;11:771053.

2. Gorshkov K, Sima N, Sun W, Lu B, Huang W, Travers J, Klumpp-Thomas C, Michael SG, Xu T, Huang R, Lee EM, Cheng X, Zheng W. Quantitative Chemotherapeutic Profiling of Gynecologic Cancer Cell Lines Using Approved Drugs and Bioactive Compounds. Transl Oncol. 2019;12(3):441-452.

3. Sima N, Sun W, Gorshkov K, Shen M, Huang W, Zhu W, Xie X, Zheng W, Cheng X. Small Molecules Identified from a Quantitative Drug Combinational Screen Resensitize Cisplatin's Response in Drug-Resistant Ovarian Cancer Cells. Transl Oncol. 2018;11(4):1053-1064.

4. Sima N, Li R, Huang W, Xu M, Beers J, Zou J, Titus S, Ottinger EA, Marugan JJ, Xie X, Zheng W. Neural stem cells for disease modeling and evaluation of therapeutics for infantile (CLN1/PPT1) and late infantile (CLN2/TPP1) neuronal ceroid lipofuscinoses. Orphanet J Rare Dis. 2018;13(1):54.

5. Sima N, Cheng X, Ye F, Ma D, Xie X, Lü W. The overexpression of scaffolding protein NEDD9 promotes migration and invasion in cervical cancer via tyrosine phosphorylated FAK and SRC. PLoS One. 2013;8(9):e74594. 

6. Sima N, Lü W, Xie X. Early proteins E6 and E7 of human papillomavirus may attenuate ischemia-reperfusion injury. Med Hypotheses. 2011;76(4):607-9.